Regenerative Cell Therapy for Corneal Endothelium
نویسندگان
چکیده
منابع مشابه
Regenerative Cell Therapy for Corneal Endothelium.
Endothelial cell dysfunction as in Fuchs dystrophy or pseudophakic bullous keratopathy, and the limited regenerative capacity of human corneal endothelial cells (HCECs), drive the need for corneal transplant. In response to limited donor corneal availability, significant effort has been directed towards cell therapy as an alternative to surgery. Stimulation of endogenous progenitors, or transpl...
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Transcorneal freezing was used to destroy the central 10, 50, or 90 percent of the endothelium in rabbit and cat cornea. The regenerative process was studied in each species by pachometry, electron microscopy, and autoradiographic analysis of the incorporation of tritiated thymidine into nuclear DNA. In rabbit, extensive cellular division occurred at the margin of the wound; in most cases an en...
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PURPOSE To isolate precursor cells derived from rabbit corneal endothelium (CE) and to use them for the treatment of CE deficiency in a rabbit model. METHODS A sphere-forming assay was performed to isolate precursor cells from rabbit CE. Immunocytochemistry was used to examine marker expressions of neural and mesenchymal cells in the sphere colonies and their progenies. The pump function of t...
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A review of the current data on the cell density of normal adult human endothelial cells was carried out in order to establish some common parameters appearing in the different considered populations. From the analysis of cell growth patterns, it is inferred that the cell aging rate is similar for each of the different considered populations. Also, the morphology, the cell distribution and the ...
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The liver can regenerate itself in response to acute liver damage. However, chronically induced liver dysfunction interferes with the liver regeneration process and increases the risk of onset of more severe hepatic failure, including hepatic cirrhosis and liver cancer. To develop more effi cient therapeutics for chronic liver diseases, cell-based regenerative therapies using functional hepatoc...
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ژورنال
عنوان ژورنال: Current Ophthalmology Reports
سال: 2014
ISSN: 2167-4868
DOI: 10.1007/s40135-014-0043-7